Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation
Abstract The inability of adult human cardiomyocytes to proliferate is an obstacle to efficient cardiac regeneration after injury.Understanding the mechanisms that drive postnatal cardiomyocytes to switch to a non-regenerative state is therefore of great significance.Here we show that Arid1a, a subunit of the switching defective/sucrose non-ferment